Ajay Kumar, PhD

Contact

E-mail

kumara6@upmc.edu

Phone

412-624-7321

Address

E1200 Biochemical Science Tower, Bay 3A, 200 Lothrop St. Pittsburgh, PA 15261

Title(s)

Research Assistant Professor
Department of Cardiothoracic Surgery

Education and Training

MS, Aligarh Muslim University, Aligarh, India - 1985
PhD, Aligarh Muslim University, Aligarh, India - 1995
Research Associate, Division of Radiation Oncology, New England Medical Center, Boston, MA - 1998-2002
Instructor, Division of Radiation Oncology, New England Medical Center, Boston, MA - 2002-2003
Instructor, Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA - 2003-2007
Research Assistant Professor, Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA - 2007-2013

Professional Activities

American Heart Association
American Society of Cell Microbiologist
American Association of Cancer Research

 

Research Interests

Molecular mechanism of ischemia reperfusion injury (I/R injury) of lung
Novel therapeutics for non-small cell lung cancer
Ex vivo lung perfusion (EVLP): the use of biomarkers to predict outcome

Publications

  1. Vikram A, Kim YR, Kumar S, Naqvi A, Hoffman A, Kumar A, Miller FJ, Kim CS, and Irani K (2014). Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species. Arteriosclerosis, Thrombosis and Vascular Biology (in press).
  2. Kumar A*, Naqvi A, Vikram A, Kumar S, Hoffman TA, Irani K (2013). Epigenetic down-regulation of endothelial Kruppel-like Factor 2 by low density lipoprotein (LDL) cholesterol. Arteriosclerosis, Thrombosis and Vascular Biology 33: 1936-42.
  3. Jung SB, , Kim CS, Kim YR , Naqvi A, Yamamori T, Kumar S, Kumar A, Irani K (2013). Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain. PLOSE ONE 8 (6): 1-11.
  4. Kim,YR, Kim CS, Naqvi A, Kumar A, Kumar S, Hoffman TA, Irani K (2012). Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction. Am J Physiol Heart Circ Physiology 303 (2): H189-196.
  5. Kim CS, Kim YR, Naqvi A, Kumar S, Hoffman TA, Jung SB, Kumar A, Jeon BH, McNamara DM, Irani K (2011). Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc. Cardiovascular Research 92(3):466-475. 
  6. Kumar A*, Kim CS, Hoffman TA, Naqvi A, DeRicco J, Lin Z, Jain MK and Irani K. P53 impairs endothelial function by transcriptionally repressing Kruppel-like factor 2 expression (2011). Arteriosclerosis, Thrombosis and Vascular Biology 31(1):133-41
  7. Naqvi A, Hoffman TA, Dericco J, Kumar A, Kim CS, Jung SB, Yamamori T, Kim YR, Mehdi F, Kumar S, Rankinen T, Ravussin E, Irani K. (2010). A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression. Human Molecular Genetics 19(21):4123-33.
  8. Jung SB, Kim CS, Naqvi A, Yamamori T, Mattagajasingh I, Hoffman TA, Cole MP, Kumar A, Dericco JS, Jeon BH, Irani K (2010). Histone Deacetylase-3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase. Circulation Research 107(7):877-87.
  9. Kumar A*, Hoffman TA, DeRicco J, Naqvi A, Jain MK and Irani K (2009). Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc. FASEB J 23(12):4344-52.
  10. Hamik A, Lin Z, Kumar A, Balcells M, Sinha S, Katz, J, Fienberg MW, Gerzsten RE, Edelman, ER and Jain MK (2007). Kruppel-like factor 4 regulates endothelial inflammation. J Biol Chem 282, 13769-79.
  11. Fisch S, Gray S, Heymans S, Haldar SM, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto Y, Liao R, Jain MK (2007). Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 104(17):7074-9.
  12. Das H, Kumar A, Lin Z, Patino WD, Hwang PM, Feinberg MW, Majumder PK, Jain MK (2006). Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci U S A.;103(17):6653-8.
  13. Kumar A, Lin Z, SenBanerjee S, and Jain MK (2005). Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol. 25, 5893-903.
  14. SenBanerjee S, Mir S, Lin Z, Hamik A, Das H, Kumar A, and Jain MK (2005). Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells. Circulation 112, 720-6.
  15. SenBanerjee, S., Lin, Z., Atkins, G.B., Greif, D.M., Rao, R.M., Kumar, A., Feinberg, M.W., Chen, Z., Simon, D.I., Luscinskas, F.W., Michel, T.M., Gimbrone, M.A., Jr., Garcia-Cardena, G. and Jain, M.K. (2004). KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med, 199, 1305-1315