Julie Phillippi, PhD

Contact

E-mail

phillippija@upmc.edu

Phone

412-624-6704

Address

450 Technology Drive, Suite 300 Pittsburgh, PA 15219

Title(s)

Assistant Professor of Cardiothoracic Surgery and Bioengineering
Department of Cardiothoracic Surgery

 

Education and Training

2000: B.S. Microbiology The Pennsylvania State University, University Park, PA
2005: Ph.D. Biological Sciences Carnegie Mellon University, Pittsburgh, PA
2005-2007: Post-doctoral fellowship, Carnegie Mellon University/Children’s Hospital of Pittsburgh of UPMC
 

Professional Activities

Biomedical Engineering Society
International Society for Applied Cardiovascular Biology
American Heart Association
Society for Free Radical Biology and Medicine

Journal Reviewing and Editorial Boards

Associate Editor, Science Advances, of the Science family of journals published by AAAS
Peer review:
• Acta Biomaterialia
• Cytometry A
• International Journal of Molecular Sciences
• Langmuir
• Journal of Biomechanics
• Journal of Developmental Biology and Tissue Engineering
• Journal of the Royal Society, Interface
• Stem Cells
• Stem Cells and Development
• Tissue Engineering
• Wound Repair and Regeneration

Awards

National Science Foundation-Young Faculty Travel Award (2015)
Tissue Engineering and Regenerative Medicine International Society-Travel Award (2007)
The Endocrine Society-Travel Award (2006)
American Society for Bone and Mineral Research-Young Investigator Award (2004)
National Institutes of Health-Pre-intramural research training award (1999)
 

Research Interests

Dr. Phillippi’s research scope broadly encompasses cell-extracellular matrix (ECM) dynamics using tissue-engineered approaches to study, diagnose and treat cardiovascular disease.  Of immediate interest is the presence of local stem cells within distinct microenvironments of the aorta and their contribution to the development and progression of aortic aneurysm. Dr. Phillippi’s projects are carried out using human aortic tissue specimens and cell populations isolated from surgical patients of the Center for Thoracic Aortic Disease at the University of Pittsburgh Medical Center. Dr. Phillippi and her colleagues within the Thoracic Aortic Disease Research Laboratory are working to characterize the influence of distinct cell populations within the ascending aorta and the role of oxidative stress pathways on aortic wall architecture, strength and propensity for aortic disease. The ultimate goal of her work is to establish novel diagnostics and risk mitigation for patients affected by thoracic aortic disease and to develop new less-invasive treatment options that aim to prevent dilatation and/or invoke reverse remodeling of the aortic wall. Dr. Phillippi is affiliated faculty of the McGowan Institute for Regenerative Medicine and the Center for Vascular Remodeling and Regeneration. More information can be found here.

Publications

  1. Krawiec, JT, Weinbaum, JS, St. Croix, CM, Phillippi, JA, Watkins, SC., Rubin, JP, and Vorp, DA. Tissue Engineering Part A. 2015. 21(3-4): 426-437.
  2. Tsamis, A, Pal, S, Phillippi, JA, Gleason, TG, Maiti, S* and Vorp, DA. Effect of Aneurysm on Biomechanical Properties of “Radially-oriented” Collagen Fibers in Human Ascending Thoracic Aortic Media. J Biomechanics. 2014 47 (16): 3820-4.
  3. Phillippi, JA, Green, BR, Eskay, MA, Kotlarczyk, MP, Hill, MR, Robertson, AM, Watkins, SC, Vorp, DA and Gleason, TG*. Mechanism of Aortic Medial Matrix Remodeling is Distinct in Bicuspid Aortic Valve Patients. JTCVS 2014. 147(3): 1056-64. **Publication of the Month-McGowan Institute for Regenerative Medicine, July 2013
  4. Tsamis, A, Phillippi, JA, Koch, RG, Pasta, S, D’Amore, A, Watkins, SC, Wagner, W, Gleason, TG and Vorp, DA*. Fiber Micro-Architecture in the Longitudinal-Radial and Circumferential-Radial Planes of Ascending Thoracic Aortic Aneurysm Media. J Biomechanics 2013. 46 (16): 2787-94.
  5. Pichamuthu, JE¥, Phillippi, JA¥, Cleary, Deborah, DA, Chew, DW, Hempel, J, Vorp, DA and Gleason, TG*. Differential Tensile Strength and Collagen Composition in Ascending Aortic Aneurysms by Aortic Valve Phenotype. Ann Thor Surg. 2013. 96 (6): 2147-54. ¥Equal contribution.
  6. Pasta, S, Phillippi, JA, Gleason, TG and Vorp, DA*. The Effect of Aneurysm on the Mechanical Dissection Properties of the Human Ascending Thoracic Aorta. Journal of Thoracic and Cardiovascular Surgery. 2012 Feb 143 (2) 460-7.
  7. Ker, EDF, Chu, B, Phillippi, J.A, Gharaibeh, B, Huard, J, Weiss, L, and Campbell, P*. Engineering Spatial Control of Multiple Differentiation Fates within a Stem Cell Population. Biomaterials. 2011 32 (13): 3413-22.
  8. Phillippi, JA, Eskay, MA, Kubala, AA, Pitt, BR and Gleason, TG*. Altered Oxidative Stress Response and Increased Type I Collagen Expression in Bicuspid Aortic Valve Patients. Ann Thor Surg. 2010. 90 (6): 1893-8.
  9. Miller, ED, Phillippi, JA, Fisher, GW, Campbell, PG, Walker, LM, and Weiss, LE*. Inkjet Printing of Growth Factor Concentration Gradients and Combinatorial Arrays Immobilized on Biologically-Relevant Substrates. Combinatorial Chemistry and Highthroughput Screening. 2009 12 (6): 604-18.
  10. Phillippi, JA, Klyachko, EA, Kenny IV JP, Eskay, MA, Gorman. RC and Gleason, TG*. Basal and Oxidative Stress-Induced Expression of Metallothionein is Decreased in Ascending Aortic Aneurysms of Bicuspid Aortic Valve Patients. Circulation. 2009. 119 (18): 2498-2506. Editorial: Coady, MA and Sellke, FW. Metallothionein Link to Bicuspid Aortic Valve Associated Ascending Aortic Dilatation. Circulation. 2009. 119: 2423-2425.
  11. Nain, A, Phillippi, JA, Sitti, M, MacKrell, J, Campbell, P and Amon, C*. Control of Cell Behavior by Aligned Micro/Nanofibrous Biomaterial Scaffolds Fabricated by Spinneret-based Tunable Engineered Parameters (STEP) Technique. Small. 2008. 4 (8): 1153-1159.
  12. Phillippi, JA*, Miller, ED, Weiss, LE, Huard, J., Waggoner, A, and Campbell, P. Microenvironments Engineered by Ink-jet Printing Spatially Direct Adult Stem Cells towards Muscle- and Bone-Like Subpopulations. Stem Cells. 2008 26: 127-134.
  13. Jadlowiec, JA, Dongell, D, Smith, J, Conover, C and Campbell, P*. PAPP-A is Involved in Matrix Mineralization of Human Adult Mesenchymal Stem Cells and Angiogenesis in the Chick CAM. Endocrinology. 2005 146 (9): 3765-72.
  14. Jadlowiec, JA, Koch, H, Zhang, X, Campbell, P, Seyedain, M, and Sfeir, C*. Phosphophoryn Affects the Gene Expression and Differentiation of NIH3T3, MC3T3-E1 and Human Adult Mesenchymal Stem Cells via Integrin/MAPK Pathway. J Biol Chem. 2004. 279 (51): p53323-30.
  15. Jadlowiec, JA, Zhang, X, Li, J, Campbell, PG, and Sfeir, C*. ECM-Mediated Signaling by Dentin Phosphophoryn Involves Activation of the Smad pathway Independent of BMP. J Biol Chem. 2006 281(9):5341-7.

Visit PubMed for a list of Dr. Phillippi's publications.