Murugesan Velayutham, PhD

Contact

E-mail

velayuthamm@upmc.edu

Address

450 Technology Drive, Room 318 Pittsburgh, PA 15219

Title(s)

Research Assistant Professor
Department of Cardiothoracic Surgery

Professional Activities

Member of the International EPR Society
Co- founding member of the Asia-Pacific EPR/ESR Society

Journal Reviewing and Editorial Boards

Senior Editor, International Journal of Applied Research in Natural Products (Open Access) - 2010

Research Interests

Dr Velayutham’s research interest has been focusing on understanding the role of free radicals, reactive oxygen species, and NO in cardiovascular biology/diseases. We apply electron paramagnetic resonance (EPR) spectroscopy and imaging techniques and various biophysical modalities to measure and map redox status in in vitro and in vivo biological systems. Our research interests also include the development of chemo-preventive drugs/biomolecules and understanding the mechanisms of these drugs/biomolecules in the application to cardiovascular diseases and organ transplantation.

Publications

  1. Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia–Reperfusion Injury. D. J. Conklin, Y. Guo, P. Haberzettl, B.G. Hill, S.P. Baba, L. Guo, D. Hoetker, G. Jagatheesan, K. Wetzelberger, D. Obal, D.G. Rokosh, R.A. Prough, S.D. Prabhu, M. Velayutham, J.L. Zweier, D.W. Riggs, S. Srivastava, R. Bolli, and A. Bhatnagar, Circulation Research 2015, 117, 437-449 (PMID: 26169370).
  2. Measurement and characterization of superoxide generation from xanthine dehydrogenase: A redox regulated pathway of radical generation in ischemic tissues. M. Lee, M. Velayutham, T. Komatsu, R. Hille, and J. L. Zweier, Biochemistry, 2014, 53, 6615-6623 (PMID: 25243829).
  3. Intraperitoneal bilirubin administration decreases infarct area in a rat coronary ischemia/reperfusion model. R. Ben-Amotz, J. Bonagura, M. Velayutham, R. Hamlin, P. Burns, and C. Adin, Frontiers in Physiology, 2014, 5, Article 53, (PMID: 24600401).
  4. Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia/reperfusion injury. M. A. Hassan Talukder, M. Elnakish, F. Yang, Y. Nishijima, M. Alhaj, M. Velayutham, H. Hassanain, and J. Zweier, American Journal of Physiology: Heart and Circulatory Physiology, 2013, 304, H294-H302 (PMID: 23161879).
  5. Early ischemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation. C. Yang, M.A. Hassan Talukder, S. Varadharaj, M. Velayutham, and J.L. Zweier, Cardiovascular Research, 2013, 97, 33-43 (PMID: 22977010).
  6. Aldehyde oxidase functions as a superoxide generating NADH oxidase: An important redox regulated pathway of cellular oxygen radical formation. T.K. Kundu, M. Velayutham, and J.L. Zweier, Biochemistry (ACS), 2012, 51, 2930-2939 (PMID: 22404107).
  7. Removal of H2O2 and generation of superoxide radical: Role of cytochrome c and NADH. M. Velayutham*, C. Hemann, and J. L. Zweier, Free Radical Biology and Medicine, 2011, 51, 160-170 (PMID: 21545835).
  8. Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to atrial electrical remodeling during chronic heart failure. Y. Nishijima, A. Sridhar, I. Bonilla, M. Velayutham, M. Khan, R. Terentyeva, C. Li, P. Kuppusamy, T.S. Elton, D. Terentyev, J.L. Zweier, A. J. Cardounel, C.A. Carnes, Cardiovascular Research, 2011, 91, 71-79 (PMID: 21460065).
  9. Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition. M. B. West, G. Rokosh, D. Obal, M. Velayutham, Y-T. Xuan, B. G. Hill, R. Keith, J. Schrader, Y. Guo, D. J. Conklin, S. D. Prabhu, J. L. Zweier, R. Bolli, and A. Bhatnagar, Circulation, 2008, 118, 1970-1978 (PMID: 18936326).
  10. In vivo atherosclerotic plaque characterization using magnetic susceptibility bistinguishes symptom-producing plaques. S. V. Raman, M. W. Winner III, T. Tran, M. Velayutham, O. P. Simonetti, P. B. Baker, B. McCarthy, A. K. Ferketich, J. Olesik, and J. L. Zweier, Journal of the American College of Cardiology: Cardiovascular Imaging, 2008, 1, 49-57 (PMID: 19356405).
  11. Targeting of phospholamban by peroxynitrite decreases –adrenergic stimulation in cardiomyocytes. M. J. Kohr, H. Wang, D. G. Wheeler, M. Velayutham, J. L. Zweier, and M. T. Ziolo, Cardiovascular Research, 2008, 77(2), 353-361 (PMID: 18006474).
  12. Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: A novel pathway for cancer chemoprevention. M. Velayutham*, R. B. Muthukumaran, J. Z. Sostaric, J. McCraken, J. C. Fishbein, and J. L. Zweier*, Free Radical Biology and Medicine, 2007, 43(7), 1076-1085 (PMID: 17761303).
  13. Glutathione mediated formation of oxygen free radicals by the major metabolite of oltipraz. M. Velayutham, F. A. Villamena, M. Navamal, J. C. Fishbein, and J. L. Zweier, Chemical Research in Toxicology, 2005, 18, 970-975 (PMID: 15962931).
  14. Mapping ischemic risk region and necrosis in the isolated heart using EPR imaging. M. Velayutham, H. Li, P. Kuppusamy, and J. L. Zweier, Magnetic Resonance in Medicine, 2003, 49, 1181-1187 (PMID: 12768597).
  15. A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal. Y. Amy Lam, T. Glen Lawson, M. Velayutham, J. L. Zweier, and C. M. Pickart, Nature, 2002, 416, 763-767 (PMID: 11961560).